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Welcome to At the Intersections. This week’s issue considers the frameworks we construct to make sense of complex phenomena. We begin with mathematical models that expose the underlying mechanics of systems, from the movement of stock prices and liquids to the operation of flexible robotic instruments. The issue then shifts to frameworks for understanding human experiences, touching on the role of information in immigrant settlement, patterns of brain activity tied to the onset of schizophrenia, and structured methods for identifying thought disorder in a person with psychosis.
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How can infrequent price changes make connected stocks look disconnected?
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In certain stock markets, prices can remain unchanged for long periods, which complicates efforts to model their behavior. Researchers modeled stock prices on the Uganda Securities Exchange by combining a model that captures constant prices with models that capture price changes.
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Nanyonga, E., Kasozi, J., Mayambala, F., Kayondo, H. W., & Davison, M. (2026). A stochastic model for illiquid stock prices and its conclusion about correlation measurement. Research in Mathematics, 13(1). https://doi.org/10.1080/27684830.2026.2680821
Matt Davison
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How can specific interview techniques reveal disorganized thinking?
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The methods for assessing formal thought disorder in a person with psychosis are often unclear, creating a gap between research-based tools and practical clinical interviews. To address this, researchers synthesized the principles and procedures from existing rating scales, translating them into an explicit framework for routine clinical use.
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Palaniyappan, L., Delgaram-Nejad, O., & Chen, E. Y. H. (2026). How to elicit thought disorder during clinical interviews: a practical guide. BJPsych Advances, 1-11. https://doi.org/10.1192/bja.2026.10213
Lena Palaniyappan
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Does a younger onset of schizophrenia alter brain activity in a way that medication cannot reverse?
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This research addresses whether the age at which schizophrenia begins creates a specific pattern of brain activity, independent of illness duration or medication. To investigate this, researchers analyzed static and dynamic brain activity from 428 participants, comparing first-episode patients with different onset ages to treated patients and healthy controls.
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Zhong, M., Yang, J., Zhang, M., Wang, F., Wang, Y., Tan, L., Liu, Z., & Palaniyappan, L. (2026). Age of onset: static and dynamic brain regional activity in first-episode drug-naïve schizophrenia. European Child & Adolescent Psychiatry. https://doi.org/10.1007/s00787-026-03056-w
Lena Palaniyappan
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How does modeling friction improve predictions for flexible robots?
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The internal friction within flexible, tendon-driven medical catheters used for procedures like cardiac ablation can lead to imprecise movement and reduced control. To address this, researchers developed a mathematical framework to simulate catheter dynamics by incorporating models for friction and tendon compliance.
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Pedrosa, F. C., Feizi, N., Arefinia, E., Jayender, J., & Patel, R. V. (2026). On Integrating Friction Dynamics Into Cosserat Models for Tendon-Driven Continuum Manipulators. IEEE/ASME Transactions on Mechatronics, 1-12. https://doi.org/10.1109/tmech.2026.3694254
Rajni V Patel
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Complex Adaptive Systems (CAS) Lab
Western University
1151 Richmond Street, London, Ontario N6A 3K7, CA
caslab@uwo.ca
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