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This week, we examine health and biology across different scales. We look at organizational barriers that can prevent the delivery of equitable care and the factors that influence medication use among women. We then turn to the brain, exploring connections between its microstructural features and the progression of neurodegenerative conditions. Finally, we zoom in to the cellular and genomic levels, considering the function of a substance in tissue formation and the consistency of nucleotide patterns within an organism's genetic code.
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What prevents cis and trans women from using HIV prevention medication?
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Globally, cis and trans women face increasing rates of HIV, yet the uptake of existing prevention medications often fails to meet their needs. To address this, researchers conducted a review of peer-reviewed published literature and synthesized findings specifically on oral PrEP.
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Barnett, T., Cloutier, D., Van Uum, R., Ebrahimpoor Mashhadi, P., Crespi, A., Tahir, H., Rana, S., Giffen, C., Haghiri-Vijeh, R., & Biondi, M. J. (2026). An Update on HIV Pre-Exposure Prophylaxis (PrEP) Among Women. Viruses, 18(6), 636. https://doi.org/10.3390/v18060636
Mia Biondi
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How does the brain's waste clearance system connect to its structure and to symptoms in ALS?
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In amyotrophic lateral sclerosis (ALS), the connection between the brain's waste clearance system, brain microstructure, and clinical symptoms is incompletely understood. To investigate this, researchers used multimodal MRI and clinical assessments to compare a group of patients with ALS to a group of healthy controls.
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Jin, X., Fu, Y., Qiu, T., Li, J., Zhang, H., Chen, Y., Chen, K., Zhang, Y., Wang, J., Yi, X., Palaniyappan, L., & Braden, B. B. (2026). Putative glymphatic dysfunction links extracellular fluid dysregulation to white matter degeneration and clinical impairment in amyotrophic lateral sclerosis. BMC Medicine. https://doi.org/10.1186/s12916-026-04948-z
Lena Palaniyappan
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Can straighter white matter pathways in the brain be a sign of more severe dementia?
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Changes to the local structure of the brain's white matter fibers in behavioral variant frontotemporal dementia (bvFTD) are not well understood. Researchers used a Director Field Analysis method to study alterations in the local geometry of white matter fibers in 51 patients with bvFTD and 51 healthy controls.
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Sun, Q., Zhang, Y., Jin, X., Cheng, J., Li, J., Qiu, T., Ren, Z., Li, K., Zhang, H., Chen, K., Palaniyappan, L., Chen, Y., Braden, B. B., & Zhang, Y. (2026). Associations of local white matter geometry with network efficiency, macrostructural abnormalities, and clinical severity in behavioral variant frontotemporal dementia. Brain Communications. https://doi.org/10.1093/braincomms/fcag226
Lena Palaniyappan
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What stops health care organizations from achieving their equity goals?
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Widening social, economic, and health inequities intensify the need for equity strategies within health care. Researchers conducted a process evaluation of an equity-focused program in three Emergency Departments by analyzing staff surveys, interviews, and observational data.
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Varcoe, C., Browne, A. J., Bungay, V., Wathen, N., Wilson, E., Byres, D., Stones, C., Dolan, S., Slemon, A., Black, A., Cater, C., Comber, S., Smye, V., & Price, E. R. (2026). How to cultivate equity-oriented health care at an organizational level: lessons from a process evaluation of EQUIP emergency. BMC Health Services Research. https://doi.org/10.1186/s12913-026-14919-y
Nadine Wathen
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Does a species' genomic signature vary within its own genome?
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The consistency of taxon-specific patterns in nucleotide composition across entire genomes, especially within repetitive regions, remains undercharacterized. Researchers addressed this by conducting a k-mer-based analysis using Frequency Chaos Game Representations across the human genome and three other eukaryotes, and by introducing computational pipelines to quantify intragenomic variation.
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Sadjadi, N., de Souza, C. P. E., Randhawa, G. S., Hill, K. A., & Kari, L. (2026). Genome-wide pervasiveness and localized variation of $$k$$-mer-based genomic signatures in eukaryotes. Scientific Reports. https://doi.org/10.1038/s41598-026-40591-7
Kathleen Hill
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Can a skin sugar help reduce abnormal scars?
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The exact reasons why keloid and hypertrophic scars form are not fully understood, and there is no definitive management approach to prevent their recurrence. To explore this, researchers reviewed scientific articles on keloid and hypertrophic scarring and a substance called hyaluronan.
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Shah, J., Bhatt, A., Yu, S., Hill, K. A., Turley, E., & Symonette, C. J. (2026). The Role of Hyaluronan in Keloid and Hypertrophic Scar Pathogenesis and Treatment. Plastic Surgery. https://doi.org/10.1177/22925503261457127
Kathleen Hill
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Upcoming events
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Western Complex Systems Conference
Mar 25, 2027 ยท 9:30 AM EDT
The purpose of the Western Complex Systems Conference is foster interdisciplinary collaboration as we explore the application of complexity theory and systems thinking across disci
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Listen to our podcast
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Complex Adaptive Systems (CAS) Lab
Western University
1151 Richmond Street, London, Ontario N6A 3K7, CA
caslab@uwo.ca
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